Combined immunodeficiency involves malfunctioning of multiple components of the immune system, including both humoral immunity and cell mediated immunity. • It is also called as “bubble boy disease” • It is X-linked genetic disorder • It characteristically lead to death from overwhelming infection in the first year of life unless they have undergone successful bone marrow transplantation. • In it neither T cells nor the B cells work properly Types : • Typical SCID • Leaky SCID • Variant SCID Clinical presentation of SCID : • Children with SCID may develop infections caused by organisms or vaccines • Organisms which are most dangerous to cause fatal diseases are: pneumonia, fungal infection, viral infections like chickenpox, CMV, influenza, measles etc. • Patients with SCID having rash are mistakenly diagnosed as eczema, but is actually caused by reaction of the mother’s T-cells. Diagnosis : • Low lymphocyte count <1500 per cubic millimeter •
Dr. Ritambhara Lohan is serving the little ones since 7 years. She practices with delicacy and warmth and ensures a good treatment for kids